
磷脂-聚乙二醇-马来酰亚胺 自组装PEG脂质体 DSPE-PEG-MAL (Maleimide functionalized PEG Lipid)
货号:RS-0000066
CAS:PEG: 25322-68-3
分子量:N/A
分子式:N/A
单位:瓶
纯度:98%
外观:固态粉末或颗粒
储存温度:冷藏密封避光
溶剂:N/A
基本信息
磷脂-聚乙二醇-马来酰亚胺自组装PEG脂质体 DSPE-PEG-MAL
DSPE-PEG-MAL是一种功能化的PEG脂质体,结合了磷脂的疏水性和聚乙二醇的亲水性,同时引入了马来酰亚胺官能团。这种结构使其能在水溶液中自发形成脂质体,并通过马来酰亚胺基团与含有巯基的药物或生物分子进行偶联,实现高效的药物装载和靶向传递。因此,DSPE-PEG-MAL在药物传递、生物偶联和生物医学研究中具有广泛应用。
DSPE-PEG-MAL是一种有用的自组装试剂,可以制备聚乙二醇化脂质体或胶束,同时提供巯基或半胱氨酸反应性马来酰亚胺基团。它通常用于靶向药物递送,与脂质双层一起提高药物溶解度,与PEG一起提供隐形特性,延长循环半衰期,减少非特异性蛋白质结合或细胞粘附,与反应性马来酰亚胺一起生物偶联靶向分子,包括抗体、适配体、蛋白质和肽。
磷脂-聚乙二醇-马来酰亚胺自组装PEG脂质体 DSPE-PEG-MAL基本信息:
中文名称:磷脂-聚乙二醇-马来酰亚胺
英文简称:DSPE-PEG-MAL
英文全称:Maleimide functionalized PEG Lipid
CAS号:n/a; PEG: 25322-68-3; DSPE: 1069-79-0
主链结构:二嵌段共聚物
亲疏水性:两亲性
产品类型:自组装PEG衍生物
外观/形态:固态粉末或颗粒(以实际外观为准)
磷脂-聚乙二醇-马来酰亚胺自组装PEG脂质体 DSPE-PEG-MAL结构式:
产地:西安
用途:科研
相关文献:
1. Thiol PEGylation of Enzymes - Matrix Metalloprotease 2-Responsive Multifunctional Liposomal Nanocarrier for Enhanced Tumor Targeting, ACS Nano, 2012, 6 (4), pp 3491–3498.
2. Thiol PEGylation of Peptides - APN/CD13-targeting as a strategy to alter the tumor accumulation of liposomes, Journal of Controlled Release 154 (2011) 298–305.
3. Self-assembly and Thiol PEGylation - Vascular targeted single-walled carbon nanotubes for near-infrared light therapy of cancer, Nanotechnology 22 (2011) 455101.
4. Self-assembly and Thiol PEGylation - Targeting single-walled carbon nanotubes for the treatment of breast cancer using photothermal therapy, 2013 Nanotechnology 24 375104
5. PEGylated Micelles and Thiol PEGylation - Aggregation-enhanced fluorescence in PEGylated phospholipid nanomicelles for in vivo imaging, Biomaterials 32 (2011) 5880e5888.
6. Intrinsically Zr-labeled Gd2O2S:Eu nanophosphors with high in vivo stability for dual modality imaging, Am JTransl Res, 2016;8(12):5591-5600.
7. Effect of microRNA-129-5p targeting HMGB1-RAGE signaling pathway on revascularization in a collagenase-induced intracerebral hemorrhage rat model, Biomedicine & Pharmacotherapy, 2017, Pages 238-244
8. Phosphatidylserine targeted single-walled carbon nanotubes for photothermal ablation of bladder cancer. Nanotechnology. 2017 Dec 13;29(3):035101.
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